Extracellular Vesicles in Airway Homeostasis and Pathophysiology

The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of homeostasis airways as well pathogenesis several diseases, including asthma and chronic obstructive pulmonary disease (COPD). “muco-microbiotic layer” (MML) innermost layer made by microbiota elements (bacteria, viruses, archaea fungi) surrounding mucous matrix. MML also crucial for maintaining healthy status organs its alteration at basis airway disorders. Nanovesicles produced EMTU are probably most important tool communication among different cell types, inflammatory ones. How nanovesicles may affect integrity, leading to onset COPD, their putative use therapy will be discussed here.